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For a common research dose in the range of 250 to 500 mcg, this difference is roughly 20 to 55 mcg, which matters in a formal pharmacokinetic study but is unlikely to be clinically decisive given that no therapeutic dose is established in humans at all

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This often shows up as skin that looks less “rough” or less reactive over time–especially when GHK-Cu is used in a routine that prioritizes barrier support rather than constant exfoliation