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Its function is to metabolize the toxic, pro-oxidant substrate heme to an antioxidant, bilirubin (this occurs through a biliverdin intermediate), and is a critical cytoprotective factor in the setting of oxidative stress.75, 76 The substrates are heme, oxygen, and reduced NAD phosphate and products are bilirubin, carbon monoxide, and iron (Figure 4)

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One 50 mg vial provides roughly 10–20 days of material at these research doses