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doi: 10.1016/j.biotechadv.2011.05.009

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When a supplement might make sense A supplement conversation can be reasonable if someone has factors like: Very low protein intake or restrictive dieting Significant gut issues affecting digestion and absorption Higher oxidative stress burden, higher toxicant exposure, or intense lifestyle strain A medical context where a clinician is monitoring symptoms and labs If none of that applies, the best first step is almost always food and fundamentals