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Semax has meaningful human clinical data compared to the Day 1 compounds, primarily from Russian clinical practice, but that data has not been independently replicated in Western controlled trials at the standard the FDA typically requires for 503A listing decisions
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The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)
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