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It has been suggested that the energy demands of chronic immune activation secondary to the shift in immunometabolism from oxidative phosphorylation to the relatively inefficient glycolysis (O'Neill et al., 2016) (described above) in conjunction with the inflammation-related systemic metabolic disturbances can in turn have an impact on valuations of future actions (Straub, 2017

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Annu Rev Pathol 7, 99–122 (2012)