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The modulatory effects of GGT-mediated prooxidant reactions could contribute to the resistance phenotype of GGT-expressing cancer cells by regulating both signal transduction pathways involved in proliferation/apoptosis balance, as well as by inducing protective adaptations in the pool of intracellular antioxidants
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62 Taken together, itaconate, its endogenous isomers, and its synthetic derivatives constitute a mechanistically related but functionally nonidentical family of metabolites
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