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Therapeutic Implications and Future Perspectives The mechanistic analyses presented in Section 3 and Section 4 establish two complementary pathways through which opioid signaling modulates altered states of consciousness: indirect engagement via serotonergic activation (classical psychedelics) and direct KOR agonism (salvinorin A)

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Unfunded Mandates Reform Act (UMRA) Section 202 of UMRA of 1995 UMRA also requires that agencies assess anticipated costs and benefits before issuing any rule whose mandates require spending in any 1 year of $100 million in 1995 dollars, updated annually for inflation