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A randomized clinical trial demonstrated that WBC modulates neurotransmitters, potentially playing a role in pain relief for fibromyalgia patients.​ Migraine & Headache Relief: Applying a frozen neck wrap targeting the carotid arteries at the onset of a migraine significantly reduced pain intensity in participants

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CPZ toxicity is linked to the induction of oxidative stress pathways, mitochondrial dysfunction and subsequent apoptosis of mature oligodendrocytes, causing demyelination in vivo and in vitro