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Research involving AOD9604 has discussed: β3-adrenergic receptor modulation Lipolysis stimulation Lipogenesis inhibition Fat oxidation enhancement Energy-expenditure signalling Adipose-tissue metabolism Metabolic flexibility investigations Cartilage-regeneration pathway research Published scientific investigations have demonstrated that AOD9604 increases β3-adrenergic receptor expression within adipose tissue and restores suppressed β3-AR RNA levels in obese murine models to levels comparable with lean control animals

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Applied immediately after ketamine, it exhibited effects on NOS-1 (decreased expression), NOS-2 (increased expression), Plcg1 (decreased expression), Prkcg (increased, and then decreased expression), and Ptgs2 (increased expression), and it had no effect on NOS-3 and Ptk2 [171]