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CTLA4 gene polymorphisms (+49A/G, CT60 A/G) are not linked to disease susceptibility, but experimental models show that CTLA4 blockade reduces ectopic lesion growth by inhibiting Treg-derived IL-10 and TGF-β ( 2.2.3 Autoimmune overlaps Endometriosis exhibits autoimmune-like features, including autoantibodies to endometrial antigens and polyclonal B-cell activation ( vs
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Cigarette smoke comprises a series of oxidants, free radicals, as well as organic components (e.g., nitric oxide and nitric superoxide) where the lung level activates the accumulation of neutrophils and macrophages, which increases the production of oxidants locally (Valavanidis et al., 2009)
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