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Each such clone will have some individual characteristic and in a special sense will be subject to an evolutionary process of selective survival within the internal environment of the body.' The gist of Burnet's theory was 'when antigen-natural antibody contact takes place on the surface of a lymphocyte the cell is activated to settle in an appropriate tissue, spleen, lymphocyte or local inflammatory accumulation, and there undergo proliferation to produce a variety of descendants' (Burnet)