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This is not always true, however, because reactive intermediates can be transported from one tissue to another, where they may exert their deleterious effects.9 For example, carcinogenic aromatic amines are metabolized in the liver to the N-hydroxylated derivatives that, following sulfation and/or acetylation conjugation, are transported to the bladder, where the N-hydroxy derivative is released under the acidic conditions of urine.16 As mentioned above, reactive metabolites are usually electrophiles or free radicals

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Size:10 ampoules x 5 ml (50ml)

through the action of CYP2E1, NDMA generates m6G, which possesses alkylating potential (Weltman et al., 1996