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In this study, we revealed that the crosstalk between androgen and Wnt/β-catenin signaling plays a major role in the increase in wool and active hair-follicle density due to the activation of c-MYC and KRTs associated with inner root sheath (IRS) in FGF5 KO sheep, and the Shh pathway is also involved in this process as a downstream pathway of Wnt/β-catenin signaling