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4 Biophysically, the ACL is subjected to complex forces that include tension, shear, and torsion, all of which can contribute to its rupture under extreme conditions
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Alternatively, ERK1/2 may act indirectly to mediate desensitization via phosphorylation of G α -interacting protein (GAIP), a regulator of G protein signaling (RGS), by potentiating the rate of GTP hydrolysis, as has been reported in some cell types (Ogier-Denis et al., 2000)
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