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Prevention vs Treatment: The Central Pattern The most consistent finding across this evidence review is that interventions effective for prevention frequently fail or cause harm in treatment: Exercise: 20% reduced dementia risk observationally, but worse outcomes in established dementia (DAPA trial) Estrogen: 32% reduced risk with midlife initiation, 32% increased risk with late-life initiation Testosterone: 39-48% increased risk with low levels, but no benefit from replacement Omega-3s: 20-64% reduced risk observationally, null in AD treatment trials OSA treatment: Strong risk association, null cognitive benefit from CPAP Valacyclovir: Epidemiological support for viral hypothesis, but worsened AD outcomes This pattern has profound implications

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Capsule Count:60 Capsules

Musch, W., Wege, A.K., Mannel, D.N

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