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glutathione essential cofactor to process vitamin b12 Folate (as THF), B6, and vitamin are required for b12 cycle
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Several of these compounds, including apigenin, chrysin, luteolin, kaempferol, quercetin, galangin, pinocembrin, naringenin, and acacetin-3-ethyl ester, have demonstrated significant biological activity [49]
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When IRP1 is attached to Fe/S clusters, it functions as a cytosolic aconitase and cannot bind to IREs on target mRNA transcripts
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