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Another drawback of the technique is that it generates 2′, 5′-phosphodiester bonds instead of the natural 3′, 5′-phosphodiester bonds
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NAD + levels increase under conditions that increase lifespan and healthspan, such as dietary restriction and exercise, and decrease during ageing or under conditions that decrease lifespan and healthspan, such as a high-fat diet, which supports the working model that decreased NAD + levels might contribute to the ageing process [57]
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