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Over time, medications may become less effective, the attacks may last longer, or pain may begin to appear between attacks

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Cell-based studies conducted under short-wavelength visible light (390–550 nm) have shown that protein damage—characterized by protein carbonylation—arises not only from direct ROS-mediated oxidation but also through secondary oxidative modifications involving reactive carbonyl species such as methylglyoxal and lipid peroxidation byproducts 145,164,165,166,167