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Shows H 2 O 2 oxidizes the LC8 leading in dissociating it from IKB-α, then IKKs phosphorylate the IKB-α resulting in free NF-Kb, which Trans locates into the nucleus and stimulates the expression of several genes which responsible for cytokine storm, shutdown the pathway of the intrinsic and extrinsic programs of cell death and transcription of mRNA of the virus