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[4] CUBN, TCN1, and the transport and absorption genes Common variants in CUBN (the ileal receptor) and TCN1 (haptocorrin) also associate with circulating B12 in GWAS
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Both pathways are linked in some cell types by the cleavage of BID, a proapoptotic member of the Bcl-2 family of proteins, generating tBID in a process catalyzed by caspase-8 activated by the extrinsic pathways (Scaffidi et al., 1998)
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