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Furthermore, it has been demonstrated that inhibiting the Wnt/ฮฒ-catenin pathway induces the overexpression of p62, leading to autophagy through the activation (dephosphorylation) and nuclear translocation of the transcription factor TFEB, inactivating the mammalian target of rapamycin (mTOR) [183]
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Moreover, mitochondrial function was assessed solely using surrogate markers such as mitochondrial mass and membrane potential
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