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The destabilization of mitochondria and generation of oxidative stress could ultimately also promote disruptions in the autophagy-lysosomal pathways (Clark et al., 2008

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For example, Williams (1935) reported selenium concentrations as high as 220 µg/L at the mouth of the Uncompahgre River and 80 µg/L in the Gunnison River near the confluence with the Colorado River

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