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Ultimately, we identified a mutant of IR35, referred to as IR35_C4, bearing the substitutions P130A, N177E and M184W, with inverted enantioselectivity, as determined by both the biosensor-based screen and chiral LC–MS, and a high enantiomeric excess of 86% (Fig

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This was certainly true for my pup and is also true for my creaky left knee