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It is possible to speculate that populations recruited into SELECT and SURPASS-CVOT trials may have been proportionately skewed towards males, in investigating intervention of weight loss in cardiovascular disease, to mimic the higher prevalence of males in each age stratum until after 75 years of age within the US population 10
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A large 24-week trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo when combined with diet and exercise
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