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In a randomized controlled trial of 100 patients with Ménière disease who presented to the emergency department for vertigo, participants received either betahistine (dosed at 8 mg every eight hours) or piracetam (800 mg every eight hours)
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(110) reported that the chicken fibroblast cells suffered from heat stress stimulate ROS and malondialdehyde (MDA) production, and it decreased the antioxidant enzymes including CAT, SOD, and GSH-Px
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