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As these ToGR are similar to GRs from bacteria, yeast and humans, it has been proposed that the counterintuitive production of ROS by GR could be widespread [191]
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An initial Phase 1a trial assessed the safety, tolerability and immunogenicity of 100μg Sh28GST expressed in Saccharomyces cerevisiae and adjuvanted with alum followed by two booster doses on day 28 and 150 in healthy adult Caucasians 18-30 years of age (NCT01512277)
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