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Following the standard synthesis and purification process, the finished DIHEXA research material undergoes an additional preparative high-performance liquid chromatography purification stage designed to reduce residual synthesis-related and process-related impurities further
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Consequently, strain-promoted azide alkyne cycloaddition (SPAAC) was developed, which only employs azide and cyclooctyne derivatives and offers slower kinetics ( k = 10 –3 – 60 M –1 s –1 )
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