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Moreover, berberine has been found to inhibit the sympathetic nervous system and stimulate the production of nitric oxide, both of which aid in the reduction of blood pressure [108]
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In addition, In vitro studies using human dopaminergic neurons derived from induced pluripotent stem cells (iPSCs) have provided critical mechanistic insights:(1) nicotine (10 μM) activates α7 nAChRs to reduce α-synuclein oligomerization and mitochondrial fission in PD patient-derived neurons, effects blocked by the selective antagonist α-bungarotoxin
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