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AAI activity toward haloalkene-derived mercapturates is widespread in mammalian tissues (Uttamsingh et al., 2000)
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Thus, changes in the GSH/GSSG ratio are fundamental in the fine-tuning of signal transduction, even under mild oxidative stress that underlies physiological events such as cell cycle regulation and other cellular processes (Schafer and Buettner, 2001)
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