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Among the tested formulations, PEGylated liposomes achieved the highest brain bioavailability after IN delivery, further confirming the effectiveness of direct nose-to-brain drug transport [166]

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Typical Clinical Ranges Loading Phase: 2–5 mg per week (subcutaneous injection) for 4–6 weeks Maintenance Phase: 2 mg every 1–2 weeks after the loading period Key Considerations Personalization: Dosage should be adjusted based on individual symptoms, sensitivities, and treatment response