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These models have led to the discovery of CRC mechanisms, including the tumour-promoting NOTCH-ABL-TRIO-RHO pathway as well as the PGE2-EP2 pathways, the invasion and metastasis-suppressing Aes gene, which inhibits NOTCH signalling [213–215]
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To clarify how the TSS pathway is activated, we first evaluated the effects of hypoxia in the presence of supraphysiological concentrations of cystine
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