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optimal absorption profile Injection sites – Abdomen, thigh, or upper arm rotation standard in protocols Formulation pH – Low pH formulation for stability and solubility Co-administration – Compatible with GLP1 in fixed-dose combination studies Study Populations in Clinical Research Human clinical trials have enrolled diverse populations: Phase 3 obesity trials – Adults with BMI greater than or equal to 30, or BMI greater than or equal to 27 with comorbidities (REDEFINE 1: 3,417 participants) Phase 3 diabetes trials – Adults with type 2 diabetes and obesity (REDEFINE 2: 1,206 participants) Phase 2 studies – Dose-finding in obesity, type 2 diabetes, and combination therapy populations Cardiovascular outcomes – REDEFINE 3 enrolling 7,000 participants with established CVD Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite extensive phase 3 clinical data published in 2025, several important questions remain under investigation regarding long-term outcomes and optimal use

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Although we consider that this period could have been enough for the neurometabolic activity (occurring during the fMRI block) to return to baseline, there are no definitive parameters regarding the time that neurometabolites return to baseline levels after cognitive effort

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