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Thus Nrf2 protein is constantly targeted for degradation by the 26S proteasome by the actions of several E3 ubiquitin ligases, including cullin–RING ubiquitin ligase, called CRL, and S-phase kinase-associated protein 1 (Skp1), cullin-1 (Cul1), F-box protein E3 ubiquitin ligase, called SCF
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