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KPV Glutathione is an endogenous γ-linked tripeptide with a reactive thiol group, whereas KPV is a short peptide fragment derived from α-MSH with a distinct sequence classification

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Acute sleep deprivation transiently increases prepro-orexin mRNA and orexin-A levels in rodents and humans, and pre-injury sleep loss can mitigate subsequent CNS damage in some models [65,66], though this remains a preventive rather than therapeutic strategy