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In the report, similar cases of exfoliative dermatitis are mentioned, with leukocytosis, hepatitis and eosinophilia in patients treated with arsenical compounds.3 In 1938, Merritt & Puttman reported their results on 142 patients with convulsive diseases treated with diphenylhydantoin
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Moreover, the selective vulnerability of specific cell types and the spatiotemporal patterns of degeneration both highlight that targeted delivery approaches will be a necessity to maximize treatment efficacy and minimize unwanted effects and toxicity
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