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CAFs can export PC, LPC, and fatty acids via exosomes, thereby delivering essential membrane lipids and metabolic intermediates directly to tumor cells
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480,481 Together, these findings underscore the central role of the LPA-LPAR axis in orchestrating chemoresistance and radioresistance through multifaceted mechanisms involving prosurvival signaling, metabolic adaptation, and DNA repair, identifying an actionable target to increase therapeutic efficacy
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