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The formation of structural disulfide bonds in proteins, for instance, is a specialized process catalyzed by oxidoreductases and thiol oxidases and occurs mostly in the endoplasmic reticulum (ER) and the mitochondrial intermembrane space (IMS) (46)

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That non-competition finding is the basis for describing the fragment as not directly engaging the GH receptor itself, though it does not by itself establish full independence from downstream IGF-1 signaling

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