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MAPK participates in the intracellular signaling to: (1) induce the gene expression of redox sensitive transcription factors, such as activator protein-1 (AP-1) and nuclear factor κB (NF-κB) (Pinkus et al., 1996), (2) stimulate apoptosis (Clement and Pervaiz, 1999), and (3) modulate cell proliferation (Lundberg et al., 2000)

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Thus, increased apoptosis during coronavirus infection contributes to increased tissue damage and pathogenesis of coronavirus infections