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These effects seem to be mediated by STAT5 as skeletal muscle-specific knockout of the STAT5 in mice results in slight increase in adiposity and worsening of insulin sensitivity (Klover and Hennighausen, 1991
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Conversely, structural genes with negative cognition coefficients broadly exhibited enrichment within excitatory neurons, namely TUBA8, NEFM, DBN1 and PALM (Fig
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