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Moreover, the least free binding energy was observed for the extracted poses of mh-Tyr-EC (− 2.67 ± 7.03 kcal/mol) and mh-Tyr-CH (− 3.68 ± 3.47 kcal/mol) from the respective MD simulation trajectories (Fig
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Furthermore, the overexpression of α-syn disrupts the interaction between mitochondria and the endoplasmic reticulum, interfering with Ca 2+ homeostasis and further inducing defects in mitochondrial fission (Tassone et al., 2023)
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