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Medication Medications for Parkinson’s disease (PD) are grouped into three main categories based on their mechanism to relieve Parkinson’s symptoms: By increasing the level of dopamine in the brain By affecting other neurotransmitters to help mitigate the symptoms By controlling non-motor symptoms A few of the major medications for Parkinson’s disease (PD) are: Levodopa: The main medication for PD is a dopamine precursor drug, known as levodopa