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Group 4 (DEX + SPAE 800): Received DEX (10 mg/kg, I/P) and SPAE orally at 800 mg/kg/day ( The 400 mg/kg and 800 mg/kg body weight/day doses for Spirulina platensis aqueous extract were selected based on previous studies demonstrating safety and hepatoprotective efficacy in rodent models (Ghallab et al., 2025), respectively