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By term, the fetal skeleton accrues approximately 28–30 g of calcium, with nearly 80% transferred during the third trimester, coinciding with rapid ossification of the collagen matrix ( Endocrine regulation A key adaptation to maintain calcium homeostasis in pregnancy is marked increase in intestinal calcium absorption, which doubles by 12 weeks of gestation, preceding the peak fetal demand later in pregnancy

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doi: 10.1371/journal.pmed.1001339