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Given that around 1% of the population in Spain follows a plant-based diet, it is possible that some of these people had a B12 deficiency due to insufficient B12 intake, thus unrelated to the presence or absence of IF antibodies

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Mutations in the enzyme Guanodinoacetate-N-Methyl Transferase ( GNMT ), which is involved in the formation of creatine, causes mental retardation, hypotonia , autism , and/or behavioural problems, including seizures (Longo etal, 2011