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Frontiers | Plant-Derived Antioxidants Protect the Nervous System From Aging by Inhibiting Oxidative Stress

Preliminary clinical studies suggest CoQ10 (300–400 mg/day) improves fatigue and sleep disturbances, but larger trials are needed for confirmation

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Since the Hebb-Williams maze is rarely used for rodents and was not employed to measure outcomes in clinical trials, conclusions are difficult to draw, in particular in the light of the role of cortical connections in human cognition and of the mixed results obtained from mice (reviewed in Kazdoba et al., 2014)