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Recently, a different class of otoprotectant, Dabrafenib (520 g/mol, LogP = 2.9) – a BRAF kinase inhibitor, was shown to cross the BLB after oral gavage in adult mice and protected the post-mitotic cochlea from cisplatin- and noise-induced hair cell death ( Systemic administration of corticosteroids have been prescribed in the clinic for otologic management of a variety of non-genetic SNHLs, including those induced by acoustic trauma (Marshak et al., 2014), SSNHL (Schreiber et al., 2010), and autoimmune inner ear disease (AIED) (Schreiber et al., 2010)
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