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(ii) Karyopyknotic cells in the affected brain areas (0–4) (score 0 indicates no change), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) were analyzed as follows: a few karyopyknotic neuronal cells (≤20%) (score 1)

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This change results in a missense change, an alanine to valine substitution, at codon 222

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