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Evidence supporting this integrated loop includes (i) transmissibility of memory and permeability phenotypes via FMT under high-altitude hypoxia (Li et al., 2025), (ii) human-to-mechanism chains linking dysbiosis to barrier dysfunction, LPS leakage, neuroinflammation, and hippocampal injury (Su et al., 2024), and (iii) canonical demonstration that microbial state can regulate BBB permeability (Braniste et al., 2014)
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