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3 is a schematic showing the caspase-1 dependent pyroptosis pathway, and IL-lb release, that C-1 Antitumor Agents, such as immuno-DASH inhibitors and other agents which induce Caspase-1 depndent pyroptosis of macrophage, are understood to trigger, as well as the induction of a prostaglandin pathway - which is consistent with the dose limiting toxicities of Talabostat

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