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Bauer DE, Harris MH, Plas DR, Lum JJ, Hammerman PS, et al
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The activated receptor complex then translocates to the nucleus and modulates gene transcription, enhancing the expression of anti-inflammatory mediators such as IL-10 and IL-1RA while suppressing proinflammatory signaling pathways through inhibition of transcription factors, including NF-κB and AP-1 (Fig
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